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What Is Methylation?

Methylation is a biochemical process that happens billions of times per second in every cell of your body. It's involved in how you produce energy, detoxify, build neurotransmitters, regulate hormones, repair DNA and manage inflammation.

When methylation isn't working properly, it can contribute to a wide range of symptoms — from fatigue, brain fog and anxiety to hormonal imbalances, poor detoxification and chronic inflammation. Many people have genetic variants (like MTHFR and COMT) that affect how efficiently these pathways run.

The good news is that while you can't change your genes, you can change how they express. With the right nutrients, lifestyle adjustments and targeted supplementation, we can support your methylation pathways to function more effectively.

DNA methylation testing at The Antidote

MTHFR, COMT and Beyond

You may have heard about MTHFR on a podcast or from a practitioner. It's an important gene, but it's just one piece of the puzzle. We look at the full picture.

MTHFR

Affects how you convert folate into its active form (methylfolate). Variants can impair methylation, increase homocysteine levels and affect mood, energy and fertility. One of the most commonly discussed genes in functional medicine.

COMT

Involved in breaking down dopamine, adrenaline and oestrogen. Variants can affect stress tolerance, anxiety levels, hormonal balance and how you respond to stimulants like caffeine.

CBS & SUOX

These genes affect how your body handles sulphur and homocysteine. Variants can influence detoxification, sensitivity to certain supplements and the transsulphuration pathway that produces glutathione — your body's master antioxidant.

GST & GPX

These detoxification genes affect how well your body clears environmental toxins, heavy metals and oxidative stress. Variants here can explain why some people are more sensitive to mould, chemicals and pollution.

The Panels We Use

We use LifecodeGx nutrigenomic panels — considered the gold standard in genetic testing for functional medicine. Each panel examines a specific area of your health.

Methylation Panel

The foundation. Analyses your methylation cycle genes including MTHFR, MTR, MTRR, BHMT and MAT to understand how you process B vitamins, folate and homocysteine.

Hormones Panel

Examines how you produce, metabolise and clear hormones — particularly oestrogen, progesterone and testosterone. Essential for fertility, PMS, PCOS and hormonal imbalances.

Nervous System Panel

Looks at genes involved in neurotransmitter production and breakdown — dopamine, serotonin, GABA and glutamate. Helps explain anxiety, mood issues, sleep problems and stress resilience.

Metabolics Panel

Analyses genes involved in energy production, blood sugar regulation, fat metabolism and mitochondrial function. Key for fatigue, weight management and metabolic health.

Detoxification Panel

Examines how your body handles environmental toxins, heavy metals, medications and chemicals. Identifies whether you're a slow detoxifier and where your pathways may need support.

Laura analysing DNA methylation results

Why Testing Matters

The internet is full of generic advice about methylation — take methylfolate, avoid folic acid, supplement with B12. But without knowing your actual genetic variants, this advice could be wrong for you, or even counterproductive.

For example, if you have a fast COMT variant, high-dose methyl donors can increase anxiety. If you have CBS upregulations, certain sulphur-containing supplements may not be well tolerated. Context matters.

We don't just hand you a genetic report and leave you to Google it. We interpret your results in the context of your symptoms, your blood work and your full health picture — then build a targeted protocol that actually makes sense for your biology.

Curious About Your Methylation?

Book a consultation and we'll discuss whether DNA methylation testing is right for you based on your symptoms and health history.

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